Some notes on Linus Pauling. 2000;71(2):530-536. Basically, it's high Vitamin C doses, accompanied by high L-Lysine, L-Proline. Proc Natl Acad Sci U S A. Am J Clin Nutr. Linus Pauling's Vit C-Lysine-Proline protocol - Ward Dean, MD Modern Nutrition in Health and Disease, 11th ed. Traxer O, Huet B, Poindexter J, Pak CY, Pearle MS. Effect of ascorbic acid consumption on urinary stone risk factors. How to Live Longer and Feel Better. 307 Linus Pauling Science Center 2004;27(4):925-930. Hansen SN, Tveden-Nyborg P, Lykkesfeldt J. 2007;12(3):230-238. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). Originally written in 2000 by: J Transl Med. Nutrition and gastric cancer risk: an update. Linus Pauling's Vitamin C Therapy: A Personal Experience Yet, most studies were small and of short duration and thus did not assess the consequence of long-term use of antioxidant vitamins on the risk of vascular complications in diabetic patients. Can J Cardiol. Vitamin C and the Common Cold. Notably, this study had several limitations (54), including no measurement of vitamin C status and the recruitment of a well-nourished study population. Subcellular Biochemistry. Int J Vitam Nutr Res. McEvoy CT, Milner KF, Scherman AJ, et al. 2014;235(1):9-20. The effect of ascorbic acid supplementation on the blood lead levels of smokers. Periprocedural myocardial injury that occurs in up to one-third of patients undergoing otherwise uncomplicated angioplasty increases the risk of morbidity and mortality at follow-up. Liability for individual actions or omissions based upon the contents of this site is expressly disclaimed. In another AD mouse model that was lacking the ability to synthesize vitamin C, supplementation with a high versus low dose of vitamin C reduced amyloid deposition in the cortex and hippocampus and limited blood-brain barrier impairments and mitochondrial dysfunction (99). Lessons learned from randomised controlled trials. Am J Obstet Gynecol. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. (PubMed), 64. Oregon State University, Updated in September 2009 by: ", Linus Pauling Institute | Oregon State University Tessier F, Moreaux V, Birlouez-Aragon I, Junes P, Mondon H. Decrease in vitamin C concentration in human lenses during cataract progression. Levy MM, Fink MP, Marshall JC, et al. Intravenous vitamin C and cancer: a systematic review. Vitamin C has been shown to increase interferon production in vitro(17). Other trials also failed to show any evidence of an effect of vitamin C on the risk of stroke. Ohno S, Ohno Y, Suzuki N, Soma G, Inoue M. High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer. (PubMed), 145. Nutr J. The effect of vitamin C, alone or with allopurinol, decreasing serum uric acid was modest and much less than that of allopurinol alone. A benefit of regular vitamin C supplementation was also seen in the duration of colds, with a greater benefit in children than in adults: The pooled effect of vitamin C supplementation was a 14% reduction in cold duration in children and an 8% reduction in adults. 1996;93(8):3704-3709. Dr. Ward Dean, MD answered 5 years ago. In the Swedish Mammography Cohort, overweight women who consumed an average of 110 mg/day of vitamin C had a 39% lower risk of breast cancer compared to overweight women who consumed an average of 31 mg/day (66). Two randomized controlled trials conducted in the 1990s reported a reduction in reperfusion-induced oxidative stress and myocardial injury with intravenous(136)or oral (137)vitamin C administration prior to CABG surgery (reviewed in 135). A 2013 meta-analysis of 53 placebo-controlled trials evaluated the effect of vitamin C supplementation on the incidence, duration, or severity of the common cold when taken as a continuous daily supplement (43 trials) or as therapy upon onset of cold symptoms (10 trials) (178). Although CSF vitamin C is maintained at concentrations several-fold higher than plasma vitamin C, the precise function of vitamin C in cognitive function and AD etiology is not yet fully understood (102). Administration of a 1-gram (g) vitamin C infusion one hour prior to the angioplasty reduced the concentrations of oxidative stress markers and improved microcirculatory perfusion compared to placebo (130). Liebman M, Chai WW, Harvey E, Boenisch L. Effect of supplemental ascorbate and orange juice on urinary oxalate. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. (PubMed), 187. (PubMed), 29. 177. A 2011 meta-analysis of 13 randomized controlled trials in healthy individuals with elevated serum uric acid revealed that vitamin C supplementation (a median dose of 500 mg/day for a median duration of 30 days) modestly reduced serum uric acid concentrations by 0.35 mg/dL compared to placebo(120). Ascorbate increases human oxaluria and kidney stone risk. BMC Ophthalmol. Vitamin C and A1c relationship in the National Health and Nutrition Examination Survey (NHANES) 2003-2006. 200. Criteria and recommendations for vitamin C intake. (PubMed), 139. The concern of kidney stone formation with vitamin C supplementation is discussed below. 2013;8(2):e56803. Bergsten P, Amitai G, Kehrl J, Dhariwal KR, Klein HG, Levine M. Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. (PubMed), 119. Khodaeian M, Tabatabaei-Malazy O, Qorbani M, Farzadfar F, Amini P, Larijani B. 2017;3:Cd011114. Eur J Clin Invest. Anderson R, Oosthuizen R, Maritz R, Theron A, Van Rensburg AJ. Calcium in this form appears to be reasonably well absorbed. Only one large trial in more than 14,000 older men participating in the Physicians Health Study II (PHS II) reported on cardiovascular outcomes. Linus Pauling's Recommendations for Vitamin C and Lysine - The Ezekiel Diet Files Linus Pauling's Recommendations for Vitamin C and Lysine by EzekielDiet.com Posted on Sep 22, 2021 Pauling's Vitamin C and Lysine dosage recommendations from his Unified Theory Lecture on Heart Disease. 2008;26(3):297-304. Hemorrhagic stroke occurs when a weakened blood vessel ruptures and bleeds into the surrounding brain tissue. In contrast, observational studies reported lower plasma vitamin C concentrations in AD patients compared to cognitively healthy subjects (101)and found better cognitive function or lower risk of cognitive impairment with higher plasma vitamin C (100). Ischemic stroke occurs when an obstruction within a blood vessel blocks blood flow to the brain. J Am Heart Assoc. (PubMed), 134. Acta Ophthalmol. Chuang CH, Sheu BS, Kao AW, et al. Production of both collagen and elastin requires vitamin C, lysine and proline. Scurvy is rare in developed countries because it can be prevented by as little as 10 mg of vitamin C daily (32). Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw KT. 2005;102(38):13604-13609. BMC Complement Altern Med. In response to invading microorganisms, phagocytic leukocytes release non-specific toxins, such as superoxide radicals, hypochlorous acid ("bleach"), and peroxynitrite; these reactive oxygen species kill pathogens and, in the process, can damage the leukocytes themselves (15). 2011;162(2):246-253. Studies in the 1970s and 1980s conducted by Linus Pauling, Ewan Cameron, and colleagues suggested that large doses of vitamin C (10 g/day infused intravenously for 10 days followed by at least 10 g/day orally indefinitely) were helpful in increasing the survival time and improving the quality of life of terminal cancer patients (158). Carter P, Gray LJ, Troughton J, Khunti K, Davies MJ. Sesso HD, Buring JE, Christen WG, et al. Free Radic Biol Med. Hutchinson J, Lentjes MA, Greenwood DC, et al. Neutrophils, mononuclear phagocytes, and lymphocytes accumulate vitamin C to high concentrations, which can protect these cell types from oxidative damage(12-14). (PubMed), 9 Vallance S. Relationships between ascorbic acid and serum proteins of the immune system. Am J Epidemiol. Urate crystals may form in joints, resulting in inflammation and pain, as well as in the kidneys and urinary tract, resulting in kidney stones. Oregon State University, Reviewed in December 2018 by: Am J Clin Nutr. Nature. The Linus Pauling Protocol - Vitamin C Vitamin C Deficiency Has Major Impact on Collagen Production Vitamin C is required to make a protein called collagen which is the major component of connective tissues. Such symptoms appear to be related to the weakening of blood vessels, connective tissue, and bone, which all contain collagen. Rautiainen S, Lindblad BE, Morgenstern R, Wolk A. Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women. (PubMed), 38. Oregon State University, Updated in November 2013 by: In order to overcome such limitations, some prospective studies measured plasma or serum concentrations of vitamin C as a more reliable index of vitamin C intake and biomarker of body vitamin C status. How to do the Rath /Pauling Therapy - Heal Yourself At Home Reversing Heart Disease | Linus Pauling | Tower Laboratories Bowman GL, Dodge H, Frei B, et al. 2014;4:283. 1999;281(15):1415-1423. Oxidative stress, neuroinflammation, -amyloid plaque deposition, Tau protein-forming tangles, and neuronal cell death in the brain of subjects affected by AD have been associated with cognitive decline and memory loss. (PubMed), 180. PDF Chapter 7 The Pauling Therapy - Practicing Medicine Without A License 1999;18(2):166-170. In a 1974 radio interview, he noted that "the first 250 mg is more important than any later 250 mg. Similarly, higher serum vitamin C concentrations were associated with decreased risks of cancer-specific and all-cause mortality in 16,008 adults from the US National Health and Nutrition Examination Survey (NHANES) III (1994-1998) (129). Ann Oncol. 2011;26(3):309-318. (PubMed), 63. The Physicians Health Study II was a randomized, placebo-controlled trial that examined the effect of vitamin E (400 IU/day), vitamin C (500 mg/day), and a multivitamin supplement on the risk of cancer in 14,641 middle-aged male physicians over 10.3 years (7.6 years of active treatment plus 2.8 years post-treatment follow-up) (82).
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